Publicaciones

2025

  1. Ancatén-González C, Meza RC, Gonzalez-Sanabria N, Segura I, Alcaino A, Peña-Pichicoi A, Latorre R, Chiu CQ, Chávez AE. (2025) BK channels mediate a presynaptic form of mGluR-LTD in the neonatal hippocampus. Proc Natl Acad Sci U S A. 122(2):e2411506122. doi: 10.1073/pnas.2411506122.
  2. Ardiles NM, Tapia V, Estay SF, Alcaino A, Velásquez VB, Sotomayor-Zárate R, Chávez AE. Moya PR. (2024). Increased forebrain EAAT3 expression confers resilience to chronic stress. J. Neurochem 169(1):e16216. doi: 10.1111/jnc.16216
  3. Balboa E, Saavedra F, Cea LA, Vargas AA, Regueira T, Sáez JC. (2025) Connexin hemichannels and early atrophic signaling in muscle during sepsis. Front Physiol. 16:1514769. doi: 10.3389/fphys.2025.1514769
  4. Contreras GF, Shen R, Latorre R, Perozo E. (2025) Structural basis of voltage-dependent gating in BK channels. Nat Commun. 16(1):5846. doi: 10.1038/s41467-025-60639-y
  5. Coronel-Oliveros C, Moguilner S, Hernandez H, Cruzat J, Baez S, Medel V, Cuadros J, Santamaria-Garcia H, Valdes-Sosa PA, Lopera F, Ochoa-Gómez JF, González- Hernández A, Bonilla-Santos J, Gonzalez-Montealegre RA, Aktürk T, Yıldırım E, Anghinah R, Legaz A, Fittipaldi Sol, Yener GG, Escudero J, Babiloni C, Lopez S, Whelan R, Fernández A, Huepe D, Di Caterina G, Soto-Añari M, Gonzalez-Gomez R, Herrera E, Abasolo D, Kilborn K, Rubido N, Clark R, Herzog R, Yerlikaya D, Güntekin Ba, Deco G, Prado P, Parra MA, Orio P, Tagliazucchi E, Lawlor B, Ibanez A (2025) Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia. Nat Mental Health. 3: 1214-1229. doi: 10.1038/s44220-025-00502-7
  6. Coronel-Oliveros C, Migeot J, Lehue F, Amoruso L, Kowalczyk-Grębska N, Jakubowska N, Mandke KN, Seabra JP, Orio P, Campbell D, Gonzalez-Gomez R, Prado P, Cuadros J, Tagliazucchi E, Cruzat J, Legaz A, Medel V, Hernandez H, Fittipaldi S, Altschuler F, Moguilner S, Baez S, Santamaria-Garcia H, González-Hernández A, Bonilla-Santos J, Güntekin B, Babiloni C, Abasolo D, Di Caterina G, Yener GG, Escudero J, Ochoa-Gómez JF, Soto-Añari M, Bruno MA, Valdes-Sosa PA, Anghinah R, Gonzalez-Montealegre RA, Clark RA, García AM, Kaltwasser L, Schürmann M, Meier JM, Brzezicka A, Whelan R, Lawlor B, Robertson IH, Bailey C, Melloni L, Sajnani N, Ibanez A. (2025) Creative experiences and brain clocks. Nat Commun. 16(1):8336. doi: 10.1038/s41467-025-64173-9
  7. De Giorgis D, Mellado G, Garate JA, Neely A.(2025) Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit. J Gen Physiol. 158(1):e202413739. doi: 10.1085/jgp.202413739.
  8. Di Berardino C, Estay SF, Alcaino A, Chávez AE. (2025) Serotonin regulates in a cell-type specific manner light-evoked response and synaptic activity in mouse retinal ganglion cells. Biol Res. 58(1):11. doi: 10.1186/s40659-025-00594-6
  9. Flores-Muñoz C, Labraña-Allende M, Mattar-Araos M, Gomez-Soto B, Silva-Guzman J, Prado-Vega L, Arriagada-Díaz J, Guerra-Fernández MJ, Bevilacqua JA, Bitoun M, Cárdenas AM, Ardiles AO, Gonzalez-Jamett AM. (2025) The synaptic availability of GluA1 is reduced in hippocampal neurons of a murine model of dynamin-2 linked autosomal dominant centronuclear myopathy. Sci Prog. 108(2):368504251332815. doi: 10.1177/00368504251332815
  10. García-Rodríguez C, Flores-Muñoz C, Fernández P, Escobar M, Ardiles ÁO, Cardenas AM, Sáez JC. (2025) Boldo leaves reduce seizures, neuroinflammation, and hemichannel activity in a murine model of chronic epilepsy. Biol Res. 58(1):72. doi: 10.1186/s40659-025-00647-w
  11. Goldmann U, Wiedmer T, Garofoli A, Sedlyarov V, Bichler M, Haladik B, Wolf G, Christodoulaki E, Ingles-Prieto A, Ferrada E, Frommelt F, Teoh ST, Leippe P, Onea G, Pfeifer M, Kohlbrenner M, Chang L, Selzer P, Reinhardt J, Digles D, Ecker GF, Osthushenrich T, MacNamara A, Malarstig A, Hepworth D, Superti-Furga G. (2025) Data- and knowledge-derived functional landscape of human solute carriers. Mol Syst Biol. 21(6):599-631. doi: 10.1038/s44320-025-00108-2
  12. Lehue F, Coronel-Oliveros C, Medel V, Liebe T, Kaufmann J, Orellana S, Becerra D, Tagliazucchi E, Orio P. (2025) Noradrenaline and acetylcholine shape functional connectivity organization of NREM substages: An empirical and simulation study. PLoS Comput Biol. 21(10):e1012852. doi: 10.1371/journal.pcbi.1012852
  13. Mellado G, Saavedra J, Lincolao-Venegas I, Garate JA, Neely A. (2025) Multiscale molecular dynamics simulations identify SNX-482/KV4.3 binding determinants. Biophys J. S0006-3495(25)00700-3. doi: 10.1016/j.bpj.2025.10.029. Online ahead of print
  14. Navarro-Quezada N, Salas-Sepulveda F, Poblete H, Naranjo D. (2025) Charybdotoxin binding to Shaker K+ channels is temperature sensitive in high external K+ but not in high external Na. J Gen Physiol. 157(5):e202413590. doi: 10.1085/jgp.202413590
  15. Olivares J, Orio P, Sadílek V, Schmachtenberg O, Canales-Johnson A. (2025) Odorant representations indicate nonlinear processing across the olfactory system. Cereb Cortex. 35(5):bhaf112. doi: 10.1093/cercor/bhaf112
  16. Palacios AG, Zhang SX, Acosta ML. (2025). Diabetic Retinopathy and Alzheimer’s Disease: Convergence of the Unfolded Protein Response in Neurodegeneration. Alzheimers Dement. 21(8):e70497. doi: 10.1002/alz.70497
  17. Palma-Espinosa J, Orellana-Villota S, Coronel-Oliveros C, Maidana JP, Orio P. (2025) The balance between integration and segregation drives network dynamics maximizing multistability and metastability. Sci Rep. 15(1):18811. doi: 10.1038/s41598-025-01612-z
  18. Pinto-Anwandter BI, Bassetto CAZ Jr, Latorre R, Bezanilla F. (2025) Energy landscape of a Kv channel revealed by temperature steps while perturbing its electromechanical coupling. Nat Commun. 16(1):3379. doi: 10.1038/s41467-025-58443-9
  19. Sáez JC, Ocaranza FJ, Prieto-Villalobos J, Orellana JA. (2025) Connexin and Pannexin Hemichannels: Broad-Spectrum Players in Neuroinflammatory Signaling. J Neurochem. 169(9):e70237. doi: 10.1111/jnc.70237
  20. Salgado M, Sepúlveda-Arriagada V, Konar-Nié M, García-Robles MA, Sáez JC. (2025) Poly (I:C)-induced inflammation requires the activation of toll-like receptor 3/Ca2+/CaMKII/pannexin 1-dependent signaling. Theranostics. 15(6):2470-2486. doi: 10.7150/thno.100687
  21. Santander O, Arredondo SB, García-Rojas F, Estay SF, Belforte JE, Chávez AE, Varela-Nallar L, Fuenzalida M. (2025) Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus. Prog Neurobiol. 246:102718. doi: 10.1016/j.pneurobio.2025.102718. Epub 2025 Jan 22
  22. Scholz-Carlson E, Iyer AR, Nern A, Ewer J, Fernandez MP. (2025) Synaptic targets of circadian clock neurons influence core clock parameters. Sci Adv. 11(36):eadw4666. doi: 10.1126/sciadv.adw4666
  23. Serey M, Retamales E, Ibañez G, Riadi G, Orio P, Castillo JP, Calixto A. (2025) Interspecies relationships of natural amoebae and bacteria with C. elegans create environments propitious for multigenerational diapause. mSystems. 10(4):e0156624. doi: 10.1128/msystems.01566-24
  24. Silva V, Scott R, Guajardo P, Luan H, Herzog R, White BH, Ewer J. (2025) Characterization of eclosion hormone receptor function reveals differential hormonal control of ecdysis during Drosophila development. PLoS Genet. 21(8):e1011672. doi: 10.1371/journal.pgen.1011672
  25. Toro CA, Zhao W, Garcia Silva P, Retamal-Santibáñez D, Rojas F, Pan J, Johnson N, Duarte Y, Cardozo CP, Sáez JC, van Zundert B. (2025) Boldine as a neuroprotective agent against motor neuron degeneration in models of amyotrophic lateral sclerosis. Front Cell Neurosci. 19:1640590. doi: 10.3389/fncel.2025.1640590
  26. Vásquez W, Toro CA, Cardozo CP, Cea LA, Sáez JC. (2025) Pathophysiological role of connexin and pannexin hemichannels in neuromuscular disorders. J Physiol. 603(15):4213-4235. doi: 10.1113/JP286173
  27. Vásquez W, Troncoso F, Lira A, Escudero C, Sáez JC (2025) Boldo Restores Vascularization and Reduces Skeletal Muscle Inflammation in Symptomatic Mice with Dysferlinopathy. Int J Mol Sci 26 (20), 9945 doi: 10.3390/ijms26209945
  28. Wang WA, Ferrada E, Klimek C, Osthushenrich T, MacNamara A, Wiedmer T, Superti-Furga G. (2025) Large-scale experimental assessment of variant effects on the structure and function of the citrate transporter SLC13A5 Sci Adv. 11(26):eadx3011. doi: 10.1126/sciadv.adx3011
  29. Wang WA, Garofoli A, Ferrada E, Klimek C, Steurer B, Ingles-Prieto A, Osthushenrich T, MacNamara A, Malarstig A, Wiedmer T, Superti-Furga G. (2025) Human genetic variants in SLC39A8 impact uptake and steady-state metal levels within the cell. Life Sci Alliance. 8(4):e202403028. doi: 10.26508/lsa.202403028

2024

  1. Ahumada-Marchant C, Ancatén-Gonzalez C, Haensgen H, Brauer B, Merino-Veliz N, Droste R, Arancibia F, Horvitz HR, Constantine-Paton M, Arriagada G, Chávez AE, Bustos FJ. (2024) Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior. BMC Biol. 22(1):142. doi: 10.1186/s12915-024-01940-y
  2. Amaya-Rodriguez CA, Carvajal-Zamorano K, Bustos D, Alegría-Arcos M, Castillo K. (2024) A journey from molecule to physiology and in silico tools for drug discovery targeting the transient receptor potential vanilloid type 1 (TRPV1) channel. Front Pharmacol. 14:1251061. doi: 10.3389/fphar.2023.1251061
  3. Asencio C, Véliz L, Flores-Faúndez E, Azócar L, Echeverría CE, Torres-Estay V, Orellana V, Ramírez-Santelices C, Sotomayor P, Cancino J, Kerr B, Fernandez-Olivares A, Retamal MA, Sáez JC, Godoy AS. (2024) Lack of canonical activities of connexins in highly aggressive human prostate cancer cells. Biol Res. 57(1):97. doi: 10.1186/s40659-024-00565-3
  4. Bayonés L, Guerra-Fernández MJ, Figueroa-Cares C, Gallo LI, Alfonso-Bueno S, Caspe O, Canal MP, Báez-Matus X, González-Jamett A, Cárdenas AM, Marengo FD. (2024) Dynamin-2 mutations linked to neonatal-onset centronuclear myopathy impair exocytosis and endocytosis in adrenal chromaffin cells. J Neurochem. 168(9):3268-3283. doi: 10.1111/jnc.16194
  5. Brauer B, Ancatén-González C, Ahumada-Marchant C, Meza RC, Merino-Veliz N, Nardocci G, Varela-Nallar L, Arriagada G, Chávez AE, Bustos FJ. (2024) Impact of KDM6B mosaic brain knockout on synaptic function and behavior. Sci Rep. 14(1):20416. doi: 10.1038/s41598-024-70728-5
  6. Castillo-Velasquez C, Matamala E, Becerra D, Orio P, Brauchi SE (2024) Optical recordings of organellar membrane potentials and the components of membrane conductance in lysosomes. J Physiol. 602(8):1637-54 . doi: 10.1113/JP283825
  7. Cavieres-Lepe J, Amini E, Zabel M, Nässel DR, Stanewsky R, Wegener C, Ewer J. (2024) Timed receptor tyrosine kinase signaling couples the central and a peripheral circadian clock in Drosophila. Proc Natl Acad Sci U S A. 121(11):e2308067121. doi: 10.1073/pnas.2308067121
  8. Caviglia A, Espinoza-Muñoz N, Alvear-Arias JJ, Galizia L, Guastaferri F, Zimmermann R, Sigaut L, Amodeo G, González C, Ozu M, Garate JA. (2024) Membrane tension-dependent conformational change of Isoleucine 106 of loop B diminishes water permeability in FaPIP2;1. Protein Sci.33(12):e5204. doi: 10.1002/pro.5204
  9. Coronel-Oliveros C, Gómez RG, Ranasinghe K, Sainz-Ballesteros A, Legaz A, Fittipaldi S, Cruzat J, Herzog R, Yener G, Parra M, Aguillon D, Lopera F, Santamaria-Garcia H, Moguilner S, Medel V, Orio P, Whelan R, Tagliazucchi E, Prado P, Ibañez A. (2024) Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole-brain modeling. Alzheimers Dement. 20(5):3228-3250. doi: 10.1002/alz.13788
  10. Coronel-Oliveros C, Medel V, Orellana S, Rodiño J, Lehue F, Cruzat J, Tagliazucchi E, Brzezicka A, Orio P, Kowalczyk-Grębska N, Ibáñez A. (2024) Gaming expertise induces meso-scale brain plasticity and efficiency mechanisms as revealed by whole-brain modeling. Neuroimage. 293: 120633. doi: 10.1016/j.neuroimage.2024.120633
  11. Coronel-Oliveros C, Medel V, Whitaker GA, Astudillo A, Gallagher D, Zepeda-Rivero L, Prado P, El-Deredy W, Orio P, Weinstein A (2023) Elevating Understanding: Linking High-Altitude Hypoxia to Brain Aging Through EEG Functional Connectivity and Spectral Analyses. Netw Neurosci 8 (1): 275–292 doi: 10.1162/netn_a_00352
  12. Cortés BI, Meza RC, Ancatén-González C, Ardiles NM, Aránguiz MI, Tomita H, Kaplan DR, Cornejo F, Nunez-Parra A, Moya PR, Chávez AE, Cancino GI. (2024) Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice. Biol Res.57(1):40. doi: 10.1186/s40659-024-00522-0
  13. Cortés MP, Alonso C, Vinet R, Valdivia-Cortés K, Muñoz-Sagredo L, Bahamondez-Canas TF, Cárdenas AM. (2024) Ca2+ signals in human umbilical endothelial cells derived from pregnancy with fetal growth restriction associated with hypertensive disorder. Biomed Rep. 20(5):76. doi: 10.3892/br.2024.1764
  14. Echeverria F, Gonzalez-Sanabria N, Alvarado-Sanchez R, Fernandez M, Castillo K, Latorre R (2024) Large conductance voltage-and calcium-activated K+ (BK) channel in health and disease. Front Pharmacol. Volume 15 – 2024 doi: 10.3389/fphar.2024.1373507
  15. Estay SF, Morales-Moraga C, Vielma AH, Palacios-Muñoz A, Chiu ChQ, Chavez AE (2024) Non-canonical CB1 receptor signaling regulates night visual processing in the inner rat retina. iScience. 109920 doi: 10.1016/j.isci.2024.109920
  16. Ferrada E, Wiedmer T, Wang WA, Frommelt F, Steurer B, Klimek C, Lindinger S, Osthushenrich T, Garofoli A, Brocchetti S, Bradberry S, Huang J, MacNamara A, Scarabottolo L, Ecker GF, Malarstig A, Superti-Furga G. (2024) Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8. J Mol Biol. 436(2):168383. doi: 10.1016/j.jmb.2023.168383
  17. Fuenzalida M, Gómez MI, Ferrada E, Díaz C, Escudero V, González-Guerrero M, Jordana X, Roschzttardtz H. (2024) Using an embryo specific promoter to modify iron distribution pattern in Arabidopsis. Plant Sci. 339:111931. doi: 10.1016/j.plantsci.2023.111931
  18. García-Rodríguez C, Duarte Y, Ardiles ÁO, Sáez JC. (2024) The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes. J Neurochem. 168(6):1045-1059. doi: 10.1111/jnc.16062
  19. Gómez GI, Alvear TF, Roa DA, Farias-Pasten A, Vergara SA, Mellado LA, Martinez-Araya CJ, Prieto-Villalobos J, García-Rodríguez C, Sánchez N, Sáez JC, Ortíz FC, Orellana JA. (2024) Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage. Biol Res. 57(1):15. doi: 10.1186/s40659-024-00493-2
  20. Gómez GI, García-Rodríguez C, Marillán JE, Vergara SA, Alvear TF, Farias-Pasten A, Sáez JC, Retamal MA, Rovegno M, Ortiz FC, Orellana JA. (2024) Acute activation of hemichannels by ethanol leads to Ca2+-dependent gliotransmitter release in astrocytes. Front Cell Dev Biol. 12:1422978. doi: 10.3389/fcell.2024.1422978
  21. González-González MA, Conde SV, Latorre R, Thébault SC, Pratelli M, Spitzer NC, Verkhratsky A, Tremblay ME, Akcora CG, Hernández-Reynoso AG, Ecker M, Coates J, Vincent KL and Ma B (2024) Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies. Front Integr Neurosci. 18:1321872. doi: 10.3389/fnint.2024.1321872
  22. «Herzog-Amunátegui H, Mora S, Prada G, Minonzio JG, Escobar MJ, Cofre R, Palacios AG (2024) A General and Accurate Method for Neuronal Ensemble Detection in Spiking Neural Networks In: Carrillo-Reid, L. (eds) Identification, Characterization, and Manipulation of Neuronal Ensembles. Neuromethods. Humana, New York, NY. Volumen 215 Número 978-1-0716-4208-5 Páginas 69-91 doi: 10.1007/978-1-0716-4208-5_3
  23. Huang J, Osthushenrich T, MacNamara A, Mälarstig A, Brocchetti S, Bradberry S, Scarabottolo L, Ferrada E, Sosnin S, Digles D, Superti-Furga G, Ecker GF. (2024) ProteoMutaMetrics: machine learning approaches for solute carrier family 6 mutation pathogenicity prediction. RSC Adv. 14(19):13083-13094. doi: 10.1039/d4ra00748d
  24. Jara O, Maripillán J, Momboisse F, Cárdenas AM, García IE, Martínez AD. (2024) Differential Regulation of Hemichannels and Gap Junction Channels by RhoA GTPase and Actin Cytoskeleton: A Comparative Analysis of Cx43 and Cx26. Int J Mol Sci. 25(13):7246. doi: 10.3390/ijms25137246
  25. Maldifassi MC, Guerra-Fernández MJ, Ponce D, Alfonso-Bueno S, Maripillán J, Vielma AH, Báez-Matus X, Marengo FD, Acuña-Castillo C, Sáez JC, Martínez AD, Cárdenas AM. (2024) Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells. Br J Pharmacol. 181(16):2905-2922. doi: 10.1111/bph.16371
  26. Nasrallah K, Berthoux C, Hashimotodani Y, Chávez AE, Gulfo MC, Luján R, Castillo PE. (2024) Retrograde adenosine/A2A receptor signaling facilitates excitatory synaptic transmission and seizures. Cell Rep. 43(7):114382. doi: 10.1016/j.celrep.2024.114382
  27. Offensperger F, Tin G, Duran-Frigola M, Hahn E, Dobner S, Ende CWA, Strohbach JW, Rukavina A, Brennsteiner V, Ogilvie K, Marella N, Kladnik K, Ciuffa R, Majmudar JD, Field SD, Bensimon A, Ferrari L, Ferrada E, Ng A, Zhang Z, Degliesposti G, Boeszoermenyi A, Martens S, Stanton R, Müller AC, Hannich JT, Hepworth D, Superti-Furga G, Kubicek S, Schenone M, Winter GE. (2024) Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 384(6694):eadk5864. doi: 10.1126/science.adk5864
  28. Okolo CA, Maran JJ, Watts A, Maripillan J, Harkiolaki M, Martínez AD, Green CR, Mugisho OO. (2024) Correlative light and X-ray tomography jointly unveil the critical role of connexin43 channels on inflammation-induced cellular ultrastructural alterations. Heliyon. 10(7):e27888. doi: 10.1016/j.heliyon.2024.e27888
  29. Palacios-Prado N, Vergara T, Sáez JC. (2024) Enhanced Methodologies for Investigating the Electrophysiological Characteristics of Endogenous Pannexin 1 Intercellular Cell-Cell Channels. Methods Mol Biol. 2801:135-145. doi: 10.1007/978-1-0716-3842-2_11
  30. Rozas-Villanueva FM, Orellana, V, Alarcón R, Maripillan J, Martinez AD, Alfaro IE, Retamal MA (2024) Cx40 Levels Regulate Hypoxia-Induced Changes in the Migration, Proliferation, and Formation of Gap Junction Plaques in An Extravillous Trophoblast Cell Model. Cells. 2024 Jul 6;13(13):1150. doi: 10.3390/cells13131150
  31. Sáez JC, Burrell JC, Cahill CM, Cullen DK, Devi LA, Gilbert RJ, Graham ZA, Gurvich VJ, Havton LA, Iyengar R, Khanna R, Palermo EF, Siddiq M, Toro CA, Vasquez W, Zhao W, Cardozo CP. (2024) Pharmacology of boldine: summary of the field and update on recent advances. Front Pharmacol. 15:1427147. doi: 10.3389/fphar.2024.1427147
  32. Salgado M, Márquez-Miranda V, Ferrada L, Rojas M, Poblete-Flores G, González-Nilo FD, Ardiles ÁO, Sáez JC. (2024) Ca2+ permeation through C-terminal cleaved, but not full-length human Pannexin1 hemichannels, mediates cell death. Proc Natl Acad Sci U S A. 121(25):e2405468121. doi: 10.1073/pnas.2405468121
  33. Tichauer JE, Lira M, Cerpa W, Orellana JA, Sáez JC, Rovegno M. (2024) Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression. Biol Res. 57(1):39. doi: 10.1186/s40659-024-00519-9
  34. Vásquez W, Toro CA, Cardozo CP, Cea LA, Sáez JC. (2024) Pathophysiological role of connexin and pannexin hemichannels in neuromuscular disorders. J Physiol. 2024 Aug 22. doi: 10.1113/JP286173. Online ahead of print
  35. Vega JL, García A, González J, Sáez JC. (2024) A Dye Uptake Assay to Measure Large-Pore Channel Activity in Trypanosoma cruzi. Methods Mol Biol. 2801:87-95. doi: 10.1007/978-1-0716-3842-2_7
  36. Villanelo F, Minogue PJ, Maripillán J, Reyna‑Jeldes M, Jensen‑Flores J, García IE, Beyer EC, Pérez‑Acle T, Berthoud VM and Martínez AD (2024) Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket. Biol Res 57:31. doi: 10.1186/s40659-024-00501-5
  37. Wegener C, Amini E, Cavieres-Lepe J, Ewer J. (2024) Neuronal and endocrine mechanisms underlying the circadian gating of eclosion: insights from Drosophila. Curr Opin Insect Sci. 66:101286. doi: 10.1016/j.cois.2024.101286

2023

  1. Abbott AC; García IE; Villanelo F; Flores-Muñoz C, Ceriani R, Maripillan J, Novoa-Molina J, Figueroa-Cares C, Pérez-Acle T, Sáez JC, Sánchez HA, Martínez AD (2023) Expression of KID syndromic mutation Cx26S17F produces hyperactive hemichannels in supporting cell of the organ of Corti. Front Cell Dev Biol 10:1071202. doi: 10.3389/fcell.2022.1071202
  2. Alvear-Arias JJ, Pena-Pichicoi A, Carrillo C, Fernandez M, Gonzalez T, Garate JA, Gonzalez C. (2023) Role of voltage-gated proton channel (Hv1) in cancer biology. Front Pharmacol. 14:1175702. doi: 10.3389/fphar.2023.1175702
  3. Ancatén-González C, Segura I, Alvarado-Sánchez R, Chávez AE and Latorre R (2023) Ca2+- and Voltage-Activated K+ (BK) Channels in the Nervous System: One Gene, a Myriad of Physiological Functions. Int J Mol Sci. 24(4), 3407 doi: 10.3390/ijms24043407
  4. Arriagada-Diaz J, Flores-Muñoz C, Gómez-Soto B, Labraña-Allende M, Mattar-Araos M, Prado-Vega L, Hinostroza F, Gajardo I, Guerra-Fernández MJ, Bevilacqua JA, Cárdenas AM, Bitoun M, Ardiles AO, Gonzalez-Jamett AM. (2023) A centronuclear myopathy-causing mutation in dynamin-2 disrupts neuronal morphology and excitatory synaptic transmission in a murine model of the disease. Neuropathol Appl Neurobiol. 49(4):e12918.  doi: 10.1111/nan.12918
  5. Barraza-Núñez N, Pérez-Núñez R, Gaete-Ramírez B, Barrios-Garrido A, Arriagada C, Poksay K, John V, Barnier JV, Cárdenas AM, Caviedes P. (2023) Pharmacological Inhibition of p-21 Activated Kinase (PAK) Restores Impaired Neurite Outgrowth and Remodeling in a Cellular Model of Down Syndrome. Neurotox Res. 41(3):256-269. doi: 10.1007/s12640-023-00638-3
  6. Bassetto CAZ Jr, Pinto BI, Latorre R, Bezanilla F. (2023) Ion channel thermodynamics studied with temperature jumps measured at the cell membrane. Biophys J. 122(4):661-671. doi: 10.1016/j.bpj.2023.01.015
  7. Bayo A, Flores V, Jaffé Y, Rojas C and Whitlock KE (2023) Bestiario Astromarino Ed. Catalonia Santiago, Chile 88 paginas ISBN: 978-956-324-813-5
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  13. Duran-Aniotz C, Poblete N, Rivera-Krstulovic C, Ardiles ÁO, Díaz ML, Tamburini G, Mae P Sabusap C, Gerakis Y, Cabral Miranda F, Diaz J, Fuentealba M, Arriagada D, Muñoz E, Espinoza S, Martinez G, Quiroz G, Medinas DB, Contreras D, Piña R, Lourenco MV, Ribeiro FC, Ferreira ST, Rozas C, Morales B, Plate L, Gonzalez-Billault C, Palacios AG, Hetz C. (2023) The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis. Mol Ther. 31(7):2240-2256. doi: 10.1016/j.ymthe.2023.03.028
  14. Fernández M, Alvear-Arias JJ, Carmona EM, Carrillo C, Pena-Pichicoi A, Hernandez-Ochoa EO, Neely A, Alvarez O, Latorre R, Garate JA, Gonzalez C (2024) Trapping Charge Mechanism in Hv1 Channels (CiHv1). Int J Mol Sci 25(1): 426, doi: 10.3390/ijms25010426
  15. García-Rodríguez C, Mujica P, Illanes-González J, López A, Vargas C, Sáez JC, González-Jamett A, Ardiles ÁO. (2023) Probenecid, an Old Drug with Potential New Uses for Central Nervous System Disorders and Neuroinflammation. Biomedicines. 11(6):1516. doi: 10.3390/biomedicines11061516
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  19. Jiménez-Madrona E, Morado-Díaz CJ, Talaverón R, Tabernero A, Pastor AM, Sáez JC, Matarredona ER. (2023) Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells. Front Neurosci. 17:1211467. doi: 10.3389/fnins.2023.1211467
  20. Li H, Guo A, Salgado M, Sáez JC, Lau CG (2023) The connexin hemichannel inhibitor D4 produces rapid antidepressant-like effects in mice. J Neuroinflammation. 20(1):191. doi: 10.1186/s12974-023-02873-z
  21. Luppi AI, Cabral J, Cofre R, Mediano PAM, Rosas FE, Qureshi AY, Kuceyeski A, Tagliazucchi E, Raimondo F, Deco G, Shine JM, Kringelbach ML, Orio P, Ching S, Sanz-Perl Y, Diringer MN, Stevens RD, Sitt JD. (2023) Computational modelling in disorders of consciousness: closing the gap towards personalised models for restoring consciousness. Neuroimage 275:120162 doi: 10.1016/j.neuroimage.2023.120162
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  23. Ozu M, Galizia L, Alvear-Arias JJ, Fernández M, Caviglia A, Zimmermann R, Guastaferri F, Espinoza-Muñoz N, Sutka M, Sigaut L, Pietrasanta LI, González C, Amodeo G & Garate JA (2023) Mechanosensitive aquaporins. Biophysical Reviews 15(4):497-513 doi: 10.1007/s12551-023-01098-x
  24. Peña-Pichicoi A, Fernández M, Navarro-Quezada N, Alvear-Arias JJ, Carrillo CA, Carmona EM, Garate J, Lopez-Rodriguez AM, Neely A, Hernández-Ochoa EO and González C (2023), N-terminal region is responsible for mHv1 channel activity in MDSCs. Front. Pharmacol. 14:1265130. doi: 10.3389/fphar.2023.1265130
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2022

  1. Alvear-Arias JJ, Carrillo C, Villar JP, Garcia-Betancourt R, Peña-Pichicoi A, Fernandez A, Fernandez M, Carmona EM, Neely A, Alvarez O, Gárate JA, Barajas-Martinez H, Larsson HP, Lopez-Rodriguez A, Latorre R and González C (2022) Expression of Hv1 proton channels in myeloid-derived suppressor cells (MDSC) and its potential role in T cell regulation. Proc Natl Acad Sci U S A. 119(15):e2104453119. doi: 10.1073/pnas.2104453119
  2. Araya-Arriagada J, Garay S, Rojas C, Duran-Aniotz C, Palacios AG, Chacón M, Medina LE. (2022) Multiscale Entropy Analysis of Retinal Signals Reveals Reduced Complexity in a Mouse Model of Alzheimer’s Disease. Scientific Report. 12(1):8900. doi: 10.1038/s41598-022-12208-2
  3. Arredondo C, Cefaliello C, Dyrda A, Jury N, Martinez P, Díaz I, Amaro A, Tran H, Morales D, Pertusa M, Stoica L, Fritz E, Corvalán D, Abarzúa S, Méndez-Ruette M, Fernández P, Rojas F, Kumar MS, Aguilar R, Almeida S, Weiss A, Bustos FJ, González-Nilo F, Otero C, Tevy MF, Bosco DA, Sáez JC, Kähne T, Gao FB, Berry JD, Nicholson K, Sena-Esteves M, Madrid R, Varela D, Montecino M, Brown RH, van Zundert B. (2022) Excessive release of inorganic phosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons. Neuron. 110(10):1656-1670.e12. doi: 10.1016/j.neuron.2022.02.010
  4. Arriagada-Diaz J, Prado-Vega L, Cárdenas Díaz AM, Ardiles AO, Gonzalez-Jamett AM. (2022) Dynamin Superfamily at Pre- and Postsynapses: Master Regulators of Synaptic Transmission and Plasticity in Health and Disease. Neuroscientist. 28(1):41-58. doi: 10.1177/1073858420974313
  5. Bayonés L, Guerra-Fernández MJ, Hinostroza F, Báez-Matus X, Vásquez-Navarrete J, Gallo LI, Parra S, Martínez AD, González-Jamett A, Marengo FD, Cárdenas AM (2022) Gain-of-Function Dynamin-2 Mutations Linked to Centronuclear Myopathy Impair Ca2+-Induced Exocytosis in Human Myoblasts. Int J Mol Sci . 23, 10363. doi: 10.3390/ijms231810363
  6. Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO Medinas D, Gerakis Y, Diaz ML, Vidal R, Fuentealba M, Miedema T, Duran-Aniotz C, Diaz J, Ibaceta-González C, Sabusap CM, Bermedo-Garcia F, Covarrubias P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi AP, Lipton SA, Kenedy BK, Henriquez JP, Cardenas JC, Plate L, Palacios AG and Hetz C.(2022)  Control of mammalian brain aging by the unfolded 1 protein response transcription factor XBP1. The EMBO J. 41(22):e111952. doi: 10.15252/embj.2022111952
  7. Cárdenas AM, Gallo LI, Marengo FD (2022) Exocytosis, endocytosis and recycling of secretory vesicles in neuroendocrine cells, and its regulation by cortical actin. BIOCELL 46(8):1867–1873. doi: 10.32604/biocell.2022.019086
  8. Carrasquel-Ursulaez W, Segura I, Dıaz-Franulic I, Echeverrıa F, Lorenzo-Ceballos Y, Espinoza N, Rojas M, Gárate JA, Perozo E, Alvarez O, Gonzalez-Nilo FD and Latorre R (2022) Mechanism of voltage sensing in Ca2+-and voltage-activated K+ (BK) channels. Proc Natl Acad Sci U S A. 119(25):e2204620119. doi: 10.1073/pnas.2204620119. doi: 10.32604/biocell.2022.019086
  9. Cortese E, Herrera A, Olivares V, Maass JC, Zelada U, Ribalta G, Vergara G, Papuzinski C, Herrada J, Martínez AD, Sánchez HA (2022) Sociodemographic and hearing profile of a population with sensorineural hearing loss in Chile.   Auditio 6, e82 doi: 10.51445/sja.auditio.vol6.2022.0082
  10. Escalona Y, Espinoza N, Barria-Urenda M, Oostenbrink C, Gárate JA. (2022) On the effects of induced polarizability at the water-graphene interface via classical charge-on-spring models. Phys Chem Chem Phys.24(13):7748-7758 doi: 10.1039/d1cp05573a.
  11. Escobar MJ, Alexandre F, Viéville T, Palacios AG. (2022). Rapid Prototyping for Bio–Inspired Robots. In Rapid Roboting: Recent Advances on 3D Printers and Robotics, Intelligent Systems, Control and Automation: Science and Engineering. Auat FA,Prieto PA, Fantoni G. editors. Springer International Publishing. Chapter 1. 82: 1-34.
  12. Flores-Muñoz C, García-Rojas F, Pérez MA, Santander O, Mery E, Ordenes S, Illanes-González J, López-Espíndola D, González-Jamett AM, Fuenzalida M, Martínez AD, Ardiles ÁO. (2022) The Long-Term Pannexin 1 Ablation Produces Structural and Functional Modifications in Hippocampal Neurons. Cells. 11(22):3646. doi: 10.3390/cells11223646.
  13. Gatica M, E Rosas F, A M Mediano P, Diez I, P Swinnen S, Orio P, Cofré R, M Cortes J. (2022)  High-order functional redundancy in ageing explained via alterations in the connectome in a whole-brain model. PLoS Comput Biol. 18(9):e1010431. doi: 10.1371/journal.pcbi.1010431.
  14. González-Jamett A, Vásquez W, Cifuentes-Riveros G, Martínez-Pando R, Sáez JC, Cárdenas AM. (2022) Oxidative Stress, Inflammation and Connexin Hemichannels in Muscular Dystrophies. Biomedicines.  10(2):507. doi: 10.3390/biomedicines10020507
  15. Guo A, Zhang H, Li H, Chiu A, García-Rodríguez C, Lagos CF, Sáez JC, Lau CG. (2022) Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy. Proc Natl Acad Sci U S A. 119(45):e2213162119. doi: 10.1073/pnas.2213162119
  16. Latorre R, Díaz-Franulic I. (2022) Profile of David Julius and Ardem Patapoutian: 2021 Nobel Laureates in Physiology or Medicine. Proc Natl Acad Sci U S A. 119(1):e2121015119. doi: 10.1073/pnas.2121015119.
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  18. Lucero CM, Marambio-Ruiz L, Balmazabal J, Prieto-Villalobos J, León M, Fernández P, Orellana JA, Velarde V, Sáez JC, Gómez GI. (2022) TNF-α Plus IL-1β Induces Opposite Regulation of Cx43 Hemichannels and Gap Junctions in Mesangial Cells through a RhoA/ROCK-Dependent Pathway. Int J Mol Sci. 2022 Sep 3;23(17):10097. doi: 10.3390/ijms231710097
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  20. Meza RC, Ancatén-González C, Chiu CQ, Chávez AE (2022) Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease. Front Cell Neurosci. 16:864828. doi: 10.3389/fncel.2022.864828
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  24. Palacios-Prado N, Soto PA, López X, Choi EJ, Marquez-Miranda V, Rojas M, Duarte Y, Lee J, González-Nilo FD, Sáez JC. (2022) Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties. Proc Natl Acad Sci U S A. 119(18):e2202104119. doi: 10.1073/pnas.2202104119.
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2021

  1. Anreiter I, Allen AM, Vasquez OE, To L, Douglas SJ, Alvarez JV, Ewer J, Sokolowski MB. (2021) The Drosophila foraging gene plays a vital role at the start of metamorphosis for subsequent adult emergence. J Neurogenet. 35(3):179-191. doi: 10.1080/01677063.2021.1914608
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  3. Bravo-Tobar ID, Fernández P, Sáez JC, Dagnino-Subiabre A. Long-Term Effects of Stress Resilience: Hippocampal Neuroinflammation and Behavioral Approach in Male Rats. J. Neurosci Res.  99(10):2493-2510. doi: 10.1002/jnr.24902
  4. Carmona EM, Fernandez M, Alvear-Arias JJ, Neely A, Larsson HP, Alvarez O, Gárate JA, Latorre R and González C (2021) The voltage sensor is responsible for ΔpH dependence in Hv1 channels.  Proc Natl Acad Sci U S A 118(19), e2025556118. doi:10.1073/pnas.2025556118
  5. Cavieres-Lepe J, Ewer J (2021) Reciprocal relationship between calcium signaling and circadian clocks: implications for calcium homeostasis, clock function, and therapeutics. Front Mol Neurosci. 14:666673. doi: 10.3389/fnmol.2021.666673
  6. Ceriani R, Whitlock KE. (2021) Gonadotropin Releasing Hormone (Gnrh) Triggers Neurogenesis in the Hypothalamus of Adult Zebrafish. Int J Mol Sci. 22(11):5926. doi: 10.3390/ijms22115926.
  7. Chang LY, Palanca-Castan N, Neira D, Palacios AG and Acosta ML (2021) Ocular Health of Octodon degus as a clinical marker for age-related and age-independent neurodegeneration. Front. Integr. Neurosci. 15:665467. doi: 10.3389/fnint.2021.665467
  8. Contreras GF, Saavedra J, Navarro-Quezada N, Mellado G, González C, Neely A. (2021) Direct inhibition of CaV2.3 by Gem is dynamin dependent and does not require a direct alfa/beta interaction. Biochem Biophys Res Commun. 586:107-113. doi: 10.1016/j.bbrc.2021.11.052.
  9. Coronel-Oliveros C, Castro S, Cofré R and Orio P (2021) Structural features of the human connectome that facilitate the switching of brain dynamics via noradrenergic neuromodulation Front. Comput. Neurosci. 15:687075. doi: 10.3389/fncom.2021.687075
  10. Coronel-Oliveros C, Cofré R, Orio P. (2021) Cholinergic neuromodulation of inhibitory interneurons facilitates functional integration in whole-brain models. PLoS Comput Biol. 17(2):e1008737. doi: 10.1371/journal.pcbi.1008737
  11. Diaz-Franulic I, Verdugo C, Gonzalez F, Gonzalez-Nilo F, and Latorre R (2021) Thermodynamic and structural basis of temperature-dependent gating in TRP channels.  Biochemical Society Transactions. 49(5):2211-2219. doi: 10.1042/BST20210301
  12. Flores-Muñoz C, Maripillán J, Vásquez-Navarrete J, Novoa-Molina J, Ceriani R, Sánchez HA, Abbott AC, Weinstein-Oppenheimer C, Brown DI, Cárdenas AM, García IE, Martínez AD. (2021) Restraint of Human Skin Fibroblast Motility, Migration, and Cell Surface Actin Dynamics, by Pannexin 1 and P2X7 Receptor Signaling. Int J Mol Sci. 22(3):1069. doi: 10.3390/ijms22031069.
  13. García-Rodríguez C, Bravo-Tobar ID, Duarte Y, Barrio LC, Sáez JC. (2021) Contribution of non-selective membrane channels and receptors in epilepsy. Pharmacol Ther. 231:107980. doi: 10.1016/j.pharmthera.2021.107980
  14. Gatica M, Cofré R, Mediano PAM, Rosas F, Orio P, Diez I, Swinnen SP, Cortes J. (2021) High-order interdependencies in the aging brain. Brain Connect. 11(9):734-744. doi: 10.1089/brain.2020.0982
  15. González-Casanova J, Schmachtenberg O, Martínez AD, Sanchez HA, Harcha PA, Rojas-Gomez D. (2021) An Update on Connexin Gap Junction and Hemichannels in Diabetic Retinopathy. Int J Mol Sci. 22(6):3194. doi: 10.3390/ijms22063194.
  16. Gonzalez-Sanabria N, Echeverria F, Segura I, Alvarado-Sánchez R, Latorre R (2021) BK in double-membrane organelles: a biophysical, pharmacological, and functional survey. Frontiers in Physiology, section Membrane Physiology and Membrane Biophysics. 12:761474. doi: 10.3389/fphys.2021.761474
  17. Granados ST, Latorre R and Torres YP (2021).  The membrane cholesterol modulates the interaction between 17-βEstradiol and the BK channel. Front Pharmacol 12:687360. doi: 10.3389/fphar.2021.687360
  18. Güiza J, Arriagada J, Rodríguez L, Gutiérrez C, Duarte Y, Sáez JC, Vega JL. (2021) Anti-parasitics drugs that modulates non-selective channels formed by connexins or pannexins. Biochim Biophys Acta Mol Basis Dis. 1867(10):166188. doi: 10.1016/j.bbadis.2021.166188
  19. Güiza J, García A, Arriagada J, Gutiérrez C, González J, Márquez-Miranda V, Alegría-Arcos M, Duarte Y, Rojas M, González-Nilo F, Sáez JC, Vega JL. (2021) Unnexins: Homologs of innexin proteins in Trypanosomatidae parasites. J Cell Physiol. 237(2):1547-1560. doi: 10.1002/jcp.30626
  20. Harcha PA, Garcés P, Arredondo C, Fernández G, Sáez JC, van Zundert B. (2021) Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer’s Disease, ALS, and Harmful Stress Conditions. Int J Mol Sci. 22(4):1924. doi: 10.3390/ijms22041924.
  21. Harcha PA, López-López T, Palacios AG, Saez PJ (2021) Pannexin channel regulation of cell migration: focus on immune cells.  Frontiers in Immunology. 12: 5124 doi: 10.3389/fimmu.2021.750480
  22. Henao JC, Grismaldo A, Barreto A, Rodríguez-Pardo VM, Mejía-Cruz CC, Leal-Garcia E, Pérez-Núñez R, Rojas P, Latorre R, Carvacho I and Torres YP (2021) TRPM8 Channel Promotes the Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells. Front. Cell Dev. Biol. 9:592946. doi: 10.3389/fcell.2021.592946
  23. Herzog R, Morales A, Mora S, Araya J, Escobar MJ, Palacios AG, and Cofré R (2021) Scalable and accurate method for neuronal ensemble detection in spiking neural networks. PLoS One. 16(7):e0251647. doi:10.1371/journal.pone.0251647
  24. Legüe M, Aguila B, Calixto A (2021) Interspecies RNA Interactome of Pathogen and Host in a Heritable Defensive Strategy. Front Microbiol. 12:649858. doi: 10.3389/fmicb.2021.649858.
  25. López X, Palacios-Prado N, Güiza J, Escamilla R, Fernández P, Vega JL, Rojas M, Marquez-Miranda V, Chamorro E, Cárdenas AM, Maldifassi MC, Martínez AD, Duarte Y, González-Nilo FD, Sáez JC. (2021) A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII. Proc Natl Acad Sci U S A.  118(32):e2108967118. doi: 10.1073/pnas.2108967118.
  26. Manterola M, Palominos MF, Calixto A (2021) The heritability of behaviors associated with the host gut microbiota. Frontiers in Immunology  12:658551. doi: 10.3389/fimmu.2021.658551
  27. Mark B, Bustos-González L, Cascallares G, Conejera F, Ewer J. (2021) The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis. Proc Natl Acad Sci U S A. 118(27):e2023249118. doi: 10.1073/pnas.2023249118.
  28. Martín P, Moncada M, Castillo K, Orsi F, Ducca G, Fernández-Fernández JM, González C, Milesi V. (2021) Arachidonic acid effect on the allosteric gating mechanism of BK (Slo1) channels associated with the β1 subunit. Biochim Biophys Acta Biomembr.1863(9):183550. doi: 10.1016/j.bbamem.2021.183550
  29. Martinez-Espinosa PL, Neely A, Ding J, Lingle CJ. (2021) Fast inactivation of Nav current in rat adrenal chromaffin cells involves two independent inactivation pathways. J Gen Physiol.  153(4):e202012784. doi: 10.1085/jgp.202012784.
  30. Mercerón-Martínez D, Ibaceta-González C, Salazar C, Almaguer-Melian W, Bergado-Rosado JA, Palacios AG (2021) Alzheimer’s Disease, Neural Plasticity, and Functional Recovery. J Alzheimers Dis. 82(s1):S37-S50. doi: 10.3233/JAD-201178
  31. Mihalas S, Ardiles A, He K, Palacios A, Kirkwood A. (2021) A Multisubcellular Compartment Model of AMPA Receptor Trafficking for Neuromodulation of Hebbian Synaptic Plasticity. Front Synaptic Neurosci. 13:703621. doi: 10.3389/fnsyn.2021.703621
  32. Orio P. (2021) Mathematical Modeling in Neuroscience. In: Zeise M.L. (eds) Neuroscience for Psychologists. Springer, Cham. Doi: doi.org/10.1007/978-3-030-47645-8_8
  33. Palominos MF, Whitlock KE. (2021) The Olfactory Organ Is Populated by Neutrophils and Macrophages During Early Development. Front Cell Dev Biol. 8:604030. doi: 10.3389/fcell.2020.604030.
  34. Pihán P, Lisbona F, Borgonovo J, Edwards-Jorquera S, Nunes-Hasler P, Castillo K, Kepp O, Urra H, Saarnio S, Vihinen H, Carreras-Sureda A, Forveille S, Sauvat A, De Giorgis D, Pupo A, Rodríguez DA, Quarato G, Sagredo A, Lourido F, Letai A, Latorre R, Kroemer G, Demaurex N, Jokitalo E, Concha ML, Glavic Á, Green DR, Hetz C. (2021) Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1. Sci Adv. 7(46):eabe5469. doi: 10.1126/sciadv.abe5469.
  35. Piñeiro M, Mena W, Ewer J, Orio P. (2021)  Extracting temporal relationships between weakly coupled peptidergic and motoneuronal signaling: Application to Drosophila ecdysis behavior. PLoS Comput Biol. 17(12):e1008933. doi: 10.1371/journal.pcbi.1008933.
  36. Rao KSJ, Britton G, Rocha Arrieta LL, Garcia-Cairasco N, Lazarowski A, Palacios A, Camins Espuny A, Maccioni RB. (2021) Translational Research and Drug Discovery for Neurodegeneration: Challenges for Latin America. J Alzheimers Dis. 82(s1):S1-S4. doi: 10.3233/JAD-210245
  37. Rivera B, Moreno C, Lavanderos B, Hwang JY, Fernández-Trillo J, Park KS, Orio P, Viana F, Madrid R, Pertusa M. (2021) Constitutive phosphorylation as a key regulator of TRPM8 channel function. J Neurosci. 41(41):8475-8493. doi: 10.1523/JNEUROSCI.0345-21.2021
  38. Salgado M, García-Robles MÁ, Sáez JC. (2021) Purinergic signaling in tanycytes and its contribution to nutritional sensing. Purinergic Signal. 17(4):607-618. doi: 10.1007/s11302-021-09791-w
  39. Savalli N, Angelini M, Steccanella F, Wier J, Wu F, Quinonez M, DiFranco M, Neely A, Cannon SC, Olcese R. (2021) The distinct role of the four voltage sensors of the skeletal CaV1.1 channel in voltage-dependent activation. J Gen Physiol. 153(11):e202112915. doi: 10.1085/jgp.202112915.
  40. Silva A, Tomassini C, Zurbrigg J, Palacios AG, Amarante V, Bouzat C (2021) Gender inequality in Latin American Neuroscience Community. IBRO Neuroscience Reports.  10: 104-108. 10.1016/j.ibneur.2021.01.006
  41. Silva V, Palacios-Muñoz A, Volonté M, Frenkel L, Ewer J, Ons S. (2021) Orcokinin neuropeptides regulate reproduction in the fruit fly, Drosophila melanogaster. Insect Biochem Mol Biol. 139:103676. doi: 10.1016/j.ibmb.2021.103676.
  42. Torres FA, Orio P, Escobar MJ (2021)  Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model  Plos Comp Biol  17(7):e1008758. doi: 10.1371/journal.pcbi.1008758
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  44. Villanelo F, Carrasco J, Jensen-Flores J, Gárate JA, Perez-Acle T. (2021) Simulations on Simple Models of Connexin Hemichannels Indicate That Ca2+ Blocking Is Not a Pure Electrostatic Effect. Membranes (Basel). 11(5):372. doi: 10.3390/membranes11050372.
  45. Wang Y, Su Y, Yu G, Wang X, Chen X, Yu B, Cheng Y, Li R, Sáez JC, Yi C, Xiao L, Niu J. (2021) Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress. Adv Sci (Weinh). 8(16):e2101181. doi: 10.1002/advs.202101181
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2020

  1. Aspé-Sánchez M, Mengotti P, Rumiati R, Rodríguez-Sickert C, Ewer J, Billeke P. (2020) Late Frontal Negativity Discriminates Outcomes and Intentions in Trust-Repayment Behavior. Front Psychol. 11:532295. doi: 10.3389/fpsyg.2020.532295.
  2. Balboa E, Saavedra F, Cea LA, Ramírez V, Escamilla R, Vargas AA, Regueira T, Sáez JC. (2020)  Vitamin E Blocks Connexin Hemichannels and Prevents Deleterious Effects of Glucocorticoid Treatment on Skeletal Muscles. Int J Mol Sci. 21(11):E4094. doi: 10.3390/ijms21114094.
  3. Barria-Urenda M, Gárate JA. (2020) Entropy deepens loading chemical potentials of small alcohols by narrow carbon nanotubes.  Phys Chem Chem Phys. 22(39):22369-22379. doi: 10.1039/d0cp03426f
  4. Castro S, El-Deredy W, Battaglia D, Orio P. (2020) Cortical ignition dynamics is tightly linked to the core organisation of the human connectome. PLoS Comput Biol. 16(7):e1007686. doi: 10.1371/journal.pcbi.1007686
  5. Cea LA, Fernández G, Arias-Bravo G, Castillo-Ruiz M, Escamilla R, Brañes MC, Sáez JC (2020) Blockade of Hemichannels Normalizes the Differentiation Fate of Myoblasts and Features of Skeletal Muscles from Dysferlin-Deficient Mice. Int J Mol Sci. 21(17):E6025. doi: 10.3390/ijms21176025.
  6. Ceriani R, Calfún C, Whitlock KE
  7. . (2020) Phoenixin(smim20), a gene coding for a novel reproductive ligand, is expressed in the brain of adult zebrafish. Gene Expr Patterns. 39:119164. doi: 10.1016/j.gep.2020.119164
  8. Chang LY, Ardiles AO, Tapia-Rojas C, Araya J, Inestrosa NC, Palacios AG, Acosta ML (2020) Evidence of synaptic and neurochemical remodeling in the retina of ageing degus. Front Neurosci 14:161. doi: 10.3389/fnins.2020.00161
  9. Choi EJ, Palacios-Prado N, Sáez JC, Lee J. (2020) Confirmation of Connexin45 Underlying Weak Gap Junctional Intercellular Coupling in HeLa Cells. Biomolecules. 10(10):E1389. doi: 10.3390/biom10101389.
  10. Cisterna BA, Vargas AA, Puebla C, Fernández P, Escamilla R, Lagos CF, Matus MF, Vilos C, Cea LA, Barnafi E, Gaete H, Escobar DF, Cardozo C, Sáez JC (2020) Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation. Nat Commun. 11(1):1073. doi: 10.1038/s41467-019-14063-8
  11. Díaz-Franulic I, Raddatz N, Castillo K, González-Nilo FD, Latorre R. (2020) A folding reaction at the C-terminal domain drives temperature sensing in TRPM8 channels. Proc Natl Acad Sci U S A. 117(33): 20298-20304. doi: 10.1073/pnas.2004303117.
  12. Du X, Carvalho-de-Souza JL, Wei C, Carrasquel-Ursulaez W, Lorenzo Y, Gonzalez N, Kubota T, Staisch J, Haine T, Petrossiana N, Xu M, Latorre R, Bezanilla F and Gomez CM (2020) Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia. Proc Natl Acad Sci U S A. 117(11):20298-20304. doi: 10.1073/pnas.1920008117
  13. Fernández G, Arias GB, Bevilacqua JA, Castillo-Ruiz M, Caviedes P, Sáez JC, Cea LA. (2020) Myofibers deficient in connexins 43 and 45 expression protect mice from skeletal muscle and systemic dysfunction promoted by a dysferlin mutation. Biochim Biophys Acta Mol Basis Dis. 1866(8):165800. doi: 10.1016/j.bbadis.2020.165800.
  14. Figueroa VA, Jara O, Oliva CA, Ezquer M, Ezquer F, Retamal MA, Martínez AD, Altenberg GA, Vargas AA. (2020) Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3) Front Physiol. 10:1574. doi: 10.3389/fphys.2019.01574.
  15. Flaven-Pouchon J, Alvarez JV, Rojas C, Ewer J. (2020) The tanning hormone, bursicon, does not act directly on the epidermis to tan the Drosophila exoskeleton. BMC Biol.18(1):17. doi: 10.1186/s12915-020-0742-5.
  16. Fuenzalida M, Chiu CQ, Chávez AE. (2020) Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus. Neuroscience. 456:50-59. doi: 10.1016/j.neuroscience.2020.08.015
  17. García-Campos P, Báez-Matus X, Jara-Gutiérrez C, Paz-Araos M, Astorga C, Cea LA, Rodríguez V, Bevilacqua JA, Caviedes P, Cárdenas AM. (2020) N-Acetylcysteine Reduces Skeletal Muscles Oxidative Stress and Improves Grip Strength in Dysferlin-Deficient Bla/J Mice. Int J Mol Sci. 21(12):E4293. doi: 10.3390/ijms21124293.
  18. Giaume CB, Naus CC, Saez JC, Leybaert L. (2020) Glial connexins and pannexins in the healthy and diseased brain. Physiol Rev. 2020 101(1):93-145. doi: 10.1152/physrev.00043.2018
  19. Hinostroza F, Neely A, Araya-Duran I, Marabolí V, Canan J, Rojas M, Aguayo D, Latorre R, González-Nilo FD, Cárdenas AM. (2020) Dynamin-2 R465W mutation induces long range perturbation in highly ordered oligomeric structures. Sci Rep.  10(1):18151. doi: 10.1038/s41598-020-75216-0.
  20. Langlet F, Sáez JC, García-Robles MA (2020)  Editorial: Involvement of Tanycytes in the Neuroendocrine Control of Energy Homeostasis. Front Endocrinol (Lausanne).  11:464. doi: 10.3389/fendo.2020.00464.
  21. López X, Escamilla R, Fernández P, Duarte Y, González-Nilo F, Palacios-Prado N, Martínez AD, Sáez JC. (2020) Stretch-Induced Activation of Pannexin 1 Channels Can Be Prevented by PKA-Dependent Phosphorylation. Int J Mol Sci. 21(23):E9180. doi: 10.3390/ijms21239180.
  22. Maldifassi MC, Momboisse F, Guerra MJ, Vielma AH, Maripillán J, Báez-Matus X, Flores-Muñoz C, Cádiz B, Schmachtenberg O, Martínez AD, Cárdenas AM (2020) The interplay between α7 nACh receptors, pannexin-1 channels and P2X7 receptors elicit exocytosis in chromaffin cells. J Neurochem. 157(6):1789-1808. doi: 10.1111/jnc.15186
  23. Moreno C, Yano S, Bezanilla F, Latorre R, Holmgren M. (2020) Transient Electrical Currents Mediated by the Na+/K+-ATPase: A Tour from Basic Biophysics to Human Diseases. Biophys J. 119: 236-242. doi: 10.1016/j.bpj.2020.06.006.              
  24. Palanca-Castan N, Harcha PA, Neira D, Palacios AG. (2020) Chromatic pupillometry for the characterization of the pupillary light reflex in Octodon degus. Exp Eye Res. 190:107866. doi: 10.1016/j.exer.2019.107866
  25. Plaza-Briceño W, Estay SF, de la Fuente-Ortega E, Gutiérrez C, Sánchez G, Hidalgo C, Chávez AE, Haeger PA. (2020) N-Methyl-d-Aspartate Receptor Modulation by Nicotinamide Adenine Dinucleotide Phosphate Oxidase Type 2 Drives Synaptic Plasticity and Spatial Memory Impairments in Rats Exposed Pre- and Postnatally to Ethanol. Antioxid Redox Signal. 32(9):602-617. doi: 10.1089/ars.2019.7787
  26. Ramírez-Barrantes R, Carvajal-Zamorano K, Rodriguez B, Cordova C, Lozano C, Simon F, Díaz P, Muñoz P, Marchant I, Latorre R, Castillo K, Olivero P. (2020) TRPV1-Estradiol Stereospecific Relationship Underlies Cell survival in Oxidative Cell Death. Front Physiol. 11:444. doi: 10.3389/fphys.2020.00444.
  27. Recabal A, Fernández P, López S, Barahona MJ, Ordenes P, Alejandra P, Elizondo-Vega R, Farkas C, Uribe A, Caprile T, Sáez JC, García-Robles MA. (2020) The FGF2-induced tanycyte proliferation involves a connexin 43 hemichannel/purinergic-dependent pathway. J Neurochem. 156(2):182-199. doi: 10.1111/jnc.15188
  28. Rivera B, Campos M, Orio P, Madrid R and María Pertusa (2020) Negative Modulation of TRPM8 Channel Function by Protein Kinase C in Trigeminal Cold Thermoreceptor Neurons Int. J. Mol. Sci.  21(12), 4420; https://doi.org/10.3390/ijms21124420
  29. Sáez JC, Contreras-Duarte S, Labra VC, Santibañez CA, Mellado LA, Inostroza CA, Alvear TF, Retamal MA, Velarde V, Orellana JA. (2020) Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage. Biochim Biophys Acta Mol Cell Res. 1867(8):118720. doi: 10.1016/j.bbamcr.2020.118720
  30. Sáez JC, Vargas AA, Hernández DE, Ortiz FC, Giaume C, Orellana JA. (2020) Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species. Int J Mol Sci. 21(11):E3970. doi: 10.3390/ijms21113970.
  31. Scott RL, Diao F, Silva V, Park S, Luan H, Ewer J, White BH. (2020) Non-canonical Eclosion Hormone-Expressing Cells Regulate Drosophila Ecdysis. iScience. 23(5):101108. doi: 10.1016/j.isci.2020.101108.
  32. Silva V, Palacios-Muñoz A, Okray Z, Adair KL, Waddell S, Douglas AE, Ewer J, . (2020) The impact of the gut microbiome on memory and sleep in Drosophila. J Exp Biol. 224(Pt 3):jeb233619. doi: 10.1242/jeb.233619.
  33. Tapia F, Olivares J, Schmachtenberg O. (2020 The visual spectral sensitivity of the Chilean recluse spider Loxosceles laeta. J Exp Biol. 223(Pt 2). pii: jeb217133. doi: 10.1242/jeb.217133
  34. Vielma AH, Tapia F, Alcaino A, Fuenzalida M, Schmachtenberg O, Chávez AE. (2020) Cannabinoid Signaling Selectively Modulates GABAergic Inhibitory Input to OFF Bipolar Cells in Rat Retina.Invest Ophthalmol Vis Sci. 61(3):3. doi: 10.1167/iovs.61.3.3

2019

  1. Alvarez O, Castillo K, Carmona E, González C y Latorre R. (2019) Methods for investigating TRP channel gating. In: Methods in Molecular Biology. Editores: Antonio Ferrer-Montiel, y Tim Hucho. Springer Publishing Company, NY, NY, USA. 1987:167-185. doi: 10.1007/978-1-4939-9446-5_11
  2. Asencio-Barría C, Defamie N, Sáez JC, Mesnil M, Godoy AS. (2019) Direct Intercellular Communications and Cancer: A Snapshot of the Biological Roles of Connexins in Prostate Cancer. Cancers (Basel). 11(9). pii: E1370. doi: 10.3390/cancers11091370
  3. Báez-Matus X, Figueroa-Cares C, Gónzalez-Jamett AM, Almarza-Salazar H, Arriagada C, Maldifassi MC, Guerra MJ, Mouly V, Bigot A, Caviedes P, Cárdenas AM. (2019) Defects in G-Actin Incorporation into Filaments in Myoblasts Derived from Dysferlinopathy Patients Are Restored by Dysferlin C2 Domains. Int J Mol Sci. 21(1). pii: E37. doi: 10.3390/ijms21010037.
  4. Bernardi M, Marracino P, Liberti M, Gárate JA, Burnham CJ, Apollonio F, English NJ (2019) Controlling ionic conductivity through transprotein electropores in human aquaporin 4: a non-equilibrium molecular-dynamics study. Phys Chem Chem Phys. 21(6):3339-3346. doi: 10.1039/c8cp06643d
  5. Calbiague V, Vielma AH, Cadiz B, Paquet-Durand F, Schmachtenberg O. (2019) Physiological assessment of high glucose neurotoxicity in mouse and rat retinal explants. J. Comp. Neurol., 528(6):989-1002. doi: 10.1002/cne.24805.
  6. Cea LA, Balboa E, Vargas AA, Puebla C, Brañes MC, Escamilla R, Regueira T, Sáez JC. (2019) De novo expression of functional connexins 43 and 45 hemichannels increases sarcolemmal permeability of skeletal myofibers during endotoxemia. Biochim Biophys Acta Mol Basis Dis. 1865(10):2765-2773. doi: 10.1016/j.bbadis.2019.06.014
  7. Chiu CQ, Barberis A, Higley MJ. (2019) Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity. Nat Rev Neurosci. 20(5):272-281. doi: 10.1038/s41583-019-0141-5
  8. Escobar AP, Wendland JR, Chávez AE, Moya PR. (2019) The Neuronal Glutamate Transporter EAAT3 in Obsessive-Compulsive Disorder. Front Pharmacol. 10:1362. doi: 10.3389/fphar.2019.01362.
  9. Eugenin EA, Valdebenito S, Gorska AM, Martínez AD, Bitran M, Sáez JC. (2019) Gap junctions coordinate the propagation of glycogenolysis induced by norepinephrine in the pineal gland. J Neurochem. 151(5):558-569 doi: 10.1111/jnc.14846.
  10. Gárate JA, Bernardin A, Escalona Y, Yanez C, English NJ, Perez-Acle T. (2019) Orientational and Folding Thermodynamics via Electric Dipole Moment Restraining. J Phys Chem B. 123(12):2599-2608 doi: 10.1021/acs.jpcb.8b09374.
  11. Giaume C, Sáez JC, Song W, Leybaert L, Naus CC. (2017) Connexins and pannexins in Alzheimer’s disease. Neurosci Lett. Neurosci Lett. 695:100-105 doi: 10.1016/j.neulet.2017.09.006
  12. Gómez GI, Velarde V, Sáez JC. (2019) Role of a RhoA/ROCK-Dependent Pathway on Renal Connexin43 Regulation in the Angiotensin II-Induced Renal Damage. Int J Mol Sci. 20(18). pii: E4408. doi: 10.3390/ijms20184408.
  13. Granados ST, Castillo K, Bravo-Moraga F, Sepúlveda RV, Carrasquel-Ursulaez W, Rojas M, Carmona E, Lorenzo-Ceballos Y, González-Nilo F, González C, Latorre R, Torres YP (2019) The molecular nature of the 17β-Estradiol binding site in the voltage- and Ca2+-activated K+ (BK) channel β1 subunit. Scientific Reports. 9(1): 9965 doi: 10.1038/s41598-019-45942-1
  14. Guerra MJ, González-Jamett AM, Báez-Matus X, Navarro-Quezada N, Martínez AD, Neely A, Cárdenas AM. (2019) The Ca2+ channel subunit CaV β2a down-regulates voltage-activated ion current densities by disrupting actin-dependent traffic in chromaffin cells. J Neurochem. 151(6):703-715. doi: 10.1111/jnc.14851
  15. Gómez GI, Velarde V and Sáez JC (2019). Connexin-Based Channels and RhoA/ROCK Pathway in Angiotensin II-Induced Kidney Damage, Selected Chapters from the Renin-Angiotensin System, Aleksandar Kibel, IntechOpen, DOI: 10.5772/intechopen.87040.
  16. Harcha PA, López X, Sáez PJ, Fernández P, Barría I, Martínez AD, Sáez JC (2019) Pannexin-1 Channels Are Essential for Mast Cell Degranulation Triggered During Type I Hypersensitivity Reactions. Front Immunol. 10:2703 doi: 10.3389/fimmu.2019.02703
  17. Li T, Niu J, Yu G, Ezan P, Yi C, Wang X, Koulakoff A, Gao X, Chen X, Sáez JC, Giaume C, Xiao L. (2019) Connexin 43 deletion in astrocytes promotes CNS remyelination by modulating local inflammation. Glia. 68(6):1201-1212. doi: 10.1002/glia.23770.
  18. Lorenzo-Ceballos Y, Carrasquel-Ursulaez W, Castillo K, Alvarez O, Latorre R. (2019) Calcium-driven regulation of voltage-sensing domains in BK channels. Elife. 8. pii: e44934. doi: 10.7554/eLife.44934.
  19. Manríquez R, Peterson SD, Prado P, Orio P, Galindo GE, Zañartu M (2019) Neurophysiological Muscle Activation Scheme For Controlling Vocal Fold Models. IEEE Trans Neural Syst Rehabil Eng. 27(5):1043-1052. Doi: 10.1109/TNSRE.2019.2906030
  20. Moya-Díaz J, Bayonés L, Montenegro M, Cárdenas AM, Koch H, Doi A, Marengo FD. (2019) Ca2+ -Independent and Voltage-Dependent Exocytosis in Mouse Chromaffin Cells. Acta Physiol (Oxf). 228(4):e13417. doi: 10.1111/apha.13417.
  21. Olivares J and Schmachtenberg O (2019) An update on anatomy and function of the teleost olfactory system. PeerJ, 7:e7808 doi: 10.7717/peerj.7808
  22. Pinto C, Medinas DB, Fuentes-Villalobos F, Maripillán J, Castro AF, Martínez AD, Osses N, Hetz C, Henríquez JP. (2019) β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation. Neurobiol Dis. 130:104497. doi: 10.1016/j.nbd.2019.104497
  23. Piña R, Ugarte G, Campos M, Íñigo-Portugués A, Olivares E, Orio P, Belmonte C, Bacigalupo J, Madrid R. (2019) Role Of TRPM8 Channels In Altered Cold Sensitivity Of Corneal Primary Sensory Neurons Induced By Axonal Damage. J Neurosci. 239(41):8177-8192. Doi: 10.1523/JNEUROSCI.0654-19.2019
  24. Ravello CR, Perrinet LU , Escobar MJ , Palacios AG (2018) Speed-Selectivity in Retinal Ganglion Cells is Sharpened by Broad Spatial Frequency, Naturalistic Stimuli. Scientific Report. 9(1):456. doi: 10.1038/s41598-018-36861-8
  25. Scala R, Maqoud F, Angelelli M, Latorre R, Perrone MG, Scilimati A, Tricarico D. (2019)  Zoledronic Acid Modulation of TRPV1 Channel Currents in Osteoblast Cell Line and Native Rat and Mouse Bone Marrow-Derived Osteoblasts: Cell Proliferation and Mineralization Effect. Cancers (Basel). 11(2). pii: E206. doi: 10.3390/cancers11020206.
  26. Whitlock K. Evolutionarily conserved peptides coordinate lunar phase and metabolism. Proc Natl Acad Sci U S A. 117 (2) 805-807. doi: 10.1073/pnas.1920432117
  27. Whitlock KE, Postlethwait J, Ewer J. (2019) Neuroendocrinology of reproduction: Is Gonadotropin-Releasing Hormone (GnRH) dispensable? Front Neuroendocrinol. 53:100738 doi: 10.1016/j.yfrne.2019.02.002. Review

2018

  1. Alvarez O, Carmona E, Latorre R & González C. (2018) A Glimpse into the Permeation Pathway of the Voltage-Dependent Proton Channel (Hv1). Comments on CrossTalk 33: Proton permeation through HV1 requires/does not require transient protonation of a conserved aspartate in the S1 transmembrane helix.  Journal of Physiology.  doi: 10.1113/JP275101
  2. Bernardi M, Marracino P, Ghaani MR, Liberti M, Del Signore F, Burnham CJ, Gárate JA, Apollonio F, English NJ. (2018) Human aquaporin 4 gating dynamics under axially oriented electric-field impulses: A non-equilibrium molecular-dynamics study. J Chem Phys. 149(24):245102. doi: 10.1063/1.5044665.
  3. Borio A, Holgado A, Gárate JA, Beyaert R, Heine H, Zamyatina A. (2018) Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation. ChemMedChem. 13(21):2317-2331 doi: 10.1002/cmdc.201800505.
  4. Carmona EM, Larsson HP, Neely A, Alvarez O, Latorre R, González C. (2018) Gating charge displacement in a monomeric voltage-gated proton (Hv1) channel.  Proc Natl Acad Sci U S A.115(37):9240-9245. doi: 10.1073/pnas.1809705115
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  12. Díaz-Franulic I, González-Pérez V, Moldenhauer H, Navarro-Quezada N, Naranjo D. (2018) Gating-induced large aqueous volumetric remodeling and aspartate tolerance in the voltage sensor domain of Shaker K+ channels. Proc Natl Acad Sci U S A. 115(32):8203-8208. doi: 10.1073/pnas.1806578115
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  18. González-Jamett AM, Bevilacqua JA and Cárdenas AM (2018) “Hereditary Myopathies”. In Muscle Cell and Tissue. Edited by Kunihiro Sakuma; Ed. InTechOpen, Chapter 6, pages 81-114. DOI: 10.5772/intechopen.76076
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  26. Vásquez-Navarrete J, Martínez AD, Ory S, Baéz-Matus X, González-Jamett AM, Brauchi S, Caviedes P, Cárdenas AM (2018) RCAN1 Knockdown Reverts Defects In The Number Of Calcium-Induced Exocytotic Events In A Cellular Model Of Down Syndrome. Front Cell Neurosci. 12:189. Doi: 10.3389/fncel.2018.00189
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